April 7, 2010: Cancer Risk and BRCA1 Missense Variants
After this lecture, you should be able to answer the following:1. Why is BRCA1 an important protein to humans?
2. Are all mutations of BRCA1 associated with an increased risk of breast or ovarian cancer? If not, which kind of mutations increase risk of disease?
3. Describe the role of the BRCT domains in the risk of BRCA1-associated breast cancer.
4. What are the strengths and limitations of using clinical data to predict cancer breast cancer risk?
5. What are the strengths and limitations of using structural analysis to predict the effect of BRCA1 mutations?
6. How can the conclusions of structural analysis of rare BRCA1 variants be validated?
7. [See Article by Carvalho et. al, 2009]. What are the goals and objectives of the study? How were these goals and objectives achieved by the authors? What was the major outcome of the study? What is the significance of their observations?
GRANT PROPOSAL RELATED:
1. Why might non-viral liposome-mediated gene therapy vectors be useful in the treatment of X-SCID?
2. What is TRPV2 and why might it be a relevant target in the treatment of multiple sclerosis?
posted by Blase Billack, Ph.D. @ 10:55 AM
0 Comments:
Post a Comment
<< Home